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human collagen i  (Proteintech)


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    Proteintech human collagen i
    Human Collagen I, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 784 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+collagen+i/Collagen+Type+I+Antibody/pm41895622-288-18-22
    Average 96 stars, based on 784 article reviews
    human collagen i - by Bioz Stars, 2026-09
    96/100 stars

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    other:

    Article Title: Nutrient availability-driven changes in extracellular matrix biochemical and mechanical properties regulate pancreatic cancer cell biology
    Article Snippet: The following primary antibodies were used: FAK p-T397, FAK (1:1,000; Cell Signaling, 13009), ERK1/2 p-T202/Y204 (1:1,000; Cell Signaling, 4377), ERK1/2 (1:1,000; Cell Signaling, 9107), mouse Collagen I (1:1,000; Abcam, ab21286), human Collagen I (1:1,000; Proteintech, 67288-1-Ig), Fibronectin (1:1,000; Abcam, ab2413), ITGA2 (1;1;000; Abcam, ab181548), β-Actin (1:5,000; Sigma, A5441), Vinculin (1:5,000; Sigma, V9131).

    Incubation:

    Article Title: Glutamine-dependent changes in fibroblast-derived extracellular matrix dictate cancer cell behavior.
    Article Snippet: The extracellular matrix (ECM) provides key biochemical and biomechanical cues that govern fundamental cellular processes, including growth and migration.. ECM dysregulation and altered cell-matrix interactions are drivers of cancer progression, exemplified by pancreatic ductal adenocarcinoma (PDAC), where an abnormally dense, collagen-rich, and stiff ECM correlates with poor patient outcomes.. The PDAC microenvironment is poorly perfused, resulting in altered nutrient availability, yet how this metabolic stress shapes the ECM and its biological activity remains largely unknown.



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    LRRC15 promotes M2 polarization by modulating the ECM production. A, Bar plot showing the enriched pathways of the upregulated genes in TGFβ-treated human CAFs compared with those of LRRC15 -KO CAFs, based on bulk RNA-seq data. B, Scatter plot showing the correlation between the ECM organization signature score and LRRC15 expression level in lung cancer from TCGA. Pearson correlation coefficient R is indicated. C, Bar plot showing the enriched pathways in human LRRC15 + CAFs from lung cancer, based on scRNA-seq data. D, Bar plot showing the enriched pathways in mouse LRRC15 + CAFs from TC1-GFP tumor co-injected with TGFβ-treated CAFs, based on scRNA-seq data. E and F, Collagen expression detected using Sirius Red staining in TGFβ-treated mouse ( E ) and human ( F ) WT or LRRC15 -KO CAFs ( n = 3 wells per group). G, Western blot plots showing <t>collagen</t> <t>I</t> expression in WT or LRRC15 -KO human CAFs treated with or without TGFβ for 48 hours. H, Sirius Red staining of tumors from Col1a2- CreER; Lrrc15 fl/fl and littermate Lrrc15 fl/fl mice bearing KPS tumors ( n = 3–4 mice per group). I, Cell number and proportion of CD206 + BMDMs in mouse BMDM and CAF ECM coculture assay ( n = 3 wells per group). J, Cell number and proportion of CD206 + mo-MΦs in human mo-MΦs and CAF ECM coculture assay ( n = 3 wells per group). K, Proportion and cell number of CD206 + mo-MΦs of CD206 in human mo-MΦs cultured with or without recombinant human collagen I ( n = 3 wells per group). Data are presented as mean ± SEM, Statistical significance was determined using the hypergeometric test ( A , C , and D ) or unpaired two-tailed Student t test ( E , F , H , I , J , and K ). P values were adjusted using the Benjamini–Hochberg method ( A , C , and D ).
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    LRRC15 promotes M2 polarization by modulating the ECM production. A, Bar plot showing the enriched pathways of the upregulated genes in TGFβ-treated human CAFs compared with those of LRRC15 -KO CAFs, based on bulk RNA-seq data. B, Scatter plot showing the correlation between the ECM organization signature score and LRRC15 expression level in lung cancer from TCGA. Pearson correlation coefficient R is indicated. C, Bar plot showing the enriched pathways in human LRRC15 + CAFs from lung cancer, based on scRNA-seq data. D, Bar plot showing the enriched pathways in mouse LRRC15 + CAFs from TC1-GFP tumor co-injected with TGFβ-treated CAFs, based on scRNA-seq data. E and F, Collagen expression detected using Sirius Red staining in TGFβ-treated mouse ( E ) and human ( F ) WT or LRRC15 -KO CAFs ( n = 3 wells per group). G, Western blot plots showing collagen I expression in WT or LRRC15 -KO human CAFs treated with or without TGFβ for 48 hours. H, Sirius Red staining of tumors from Col1a2- CreER; Lrrc15 fl/fl and littermate Lrrc15 fl/fl mice bearing KPS tumors ( n = 3–4 mice per group). I, Cell number and proportion of CD206 + BMDMs in mouse BMDM and CAF ECM coculture assay ( n = 3 wells per group). J, Cell number and proportion of CD206 + mo-MΦs in human mo-MΦs and CAF ECM coculture assay ( n = 3 wells per group). K, Proportion and cell number of CD206 + mo-MΦs of CD206 in human mo-MΦs cultured with or without recombinant human collagen I ( n = 3 wells per group). Data are presented as mean ± SEM, Statistical significance was determined using the hypergeometric test ( A , C , and D ) or unpaired two-tailed Student t test ( E , F , H , I , J , and K ). P values were adjusted using the Benjamini–Hochberg method ( A , C , and D ).

    Journal: Cancer Research

    Article Title: Targeting LRRC15 in Cancer-Associated Fibroblasts Modifies the Extracellular Matrix and Enhances Tumor Immune Responses to Suppress Lung Cancer Progression

    doi: 10.1158/0008-5472.CAN-25-2871

    Figure Lengend Snippet: LRRC15 promotes M2 polarization by modulating the ECM production. A, Bar plot showing the enriched pathways of the upregulated genes in TGFβ-treated human CAFs compared with those of LRRC15 -KO CAFs, based on bulk RNA-seq data. B, Scatter plot showing the correlation between the ECM organization signature score and LRRC15 expression level in lung cancer from TCGA. Pearson correlation coefficient R is indicated. C, Bar plot showing the enriched pathways in human LRRC15 + CAFs from lung cancer, based on scRNA-seq data. D, Bar plot showing the enriched pathways in mouse LRRC15 + CAFs from TC1-GFP tumor co-injected with TGFβ-treated CAFs, based on scRNA-seq data. E and F, Collagen expression detected using Sirius Red staining in TGFβ-treated mouse ( E ) and human ( F ) WT or LRRC15 -KO CAFs ( n = 3 wells per group). G, Western blot plots showing collagen I expression in WT or LRRC15 -KO human CAFs treated with or without TGFβ for 48 hours. H, Sirius Red staining of tumors from Col1a2- CreER; Lrrc15 fl/fl and littermate Lrrc15 fl/fl mice bearing KPS tumors ( n = 3–4 mice per group). I, Cell number and proportion of CD206 + BMDMs in mouse BMDM and CAF ECM coculture assay ( n = 3 wells per group). J, Cell number and proportion of CD206 + mo-MΦs in human mo-MΦs and CAF ECM coculture assay ( n = 3 wells per group). K, Proportion and cell number of CD206 + mo-MΦs of CD206 in human mo-MΦs cultured with or without recombinant human collagen I ( n = 3 wells per group). Data are presented as mean ± SEM, Statistical significance was determined using the hypergeometric test ( A , C , and D ) or unpaired two-tailed Student t test ( E , F , H , I , J , and K ). P values were adjusted using the Benjamini–Hochberg method ( A , C , and D ).

    Article Snippet: For macrophage–collagen stimulation assays, 500 μg/mL human collagen I (MedChemExpress, cat. #HY-NP160) was coated in 12-well plates for culturing mo-MΦs.

    Techniques: RNA Sequencing, Expressing, Injection, Staining, Western Blot, Co-culture Assay, Cell Culture, Recombinant, Two Tailed Test